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Volume 16, Issue 37, 2022 (In Progress)

About the Cover

Salmonella can be found worldwide, although the distribution of serovars may vary. Salmonella are well known pathogens, highly adaptive and potentially pathogenic for humans and animals. Salmonella infections are capable of producing serious infections that are often food borne and present as gastroenteritis. Serotypes adapted to men, such as Salmonella typhi and Salmonella paratyphi, usually cause severe diseases in humans as a septicaemic typhoid syndrome (enteric fever).The present study investigates the occurrence of sul3 gene in the DNA, characterization of protein to check the virulence and analyze the multi resistance of Salmonella typhi to various drugs. The present study confirmed the expression of sul3 gene which showed the resistance to Sulfonamides. The growth in the medium containing drugs showed multiresistance of S.typhi.


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REPORT

Characteristic Study of sul3 gene expression, protein profiling and multi resistance in Salmonella typhi

Sudhin AS

Salmonella can be found worldwide, although the distribution of serovars may vary. Salmonella are well known pathogens, highly adaptive and potentially pathogenic for humans and animals

Drug Discovery, 2022, 16(37), 1-8

Abstract | PDF

ANALYSIS

Molecular docking study of potential phytochemicals of Tinospora cordifolia (Giloy) and Glycyrrhiza glabra (Mulethi) and their effect on the complex SARS-CoV2 Mpro& RdRp

Pandey J, Mishra SK

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) previously convened 2019 novel coronavirus is the responsible for coronavirus disease 2019 (COVID-19), a disease lately state a global public health crisis by the World Health Organization (WHO).

Drug Discovery, 2022, 16(37), 9-17

Abstract | PDF

Antagonizing the interplay between SARS-CoV-2 viral RNA polymerase components and the host transcriptional machinery with Thrombin, Plasmin & Cysteine Protease as a potential mechanism of interference with viral RNA synthesis

Bhanu P, Kumar NH, Buchke S, Anand DA, Kumar J

For the expression of their genes, viruses need the host transcriptional machinery. There is a lot of evidence that suggests that cellular factors are subverted by RNA viruses, many of which are used as replication factors

Drug Discovery, 2022, 16(37), 18-28

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REPORT

Antibacterial and antifungal activities of tobramycin, gentamycin, neomycin and amikacin derivatives, derived from vanillin

Munan A, Khan AJ, Khan M, Abbas G, Ahmad E, Hussain A, Khan S, Khan AK, Yousaf AH

Vanillin was used to synthesis a number of derivatives of Tobramycin, Gentamycin, Neomycin, and Amikacin. The creation of the imine bond and its reduction with NaBH4 were accomplished

Drug Discovery, 2022, 16(37), 29-35

Abstract | PDF

RESEARCH

Hepatotoxic impact of desloratadine/dihydroartemisinin/piperaquine on healthy and parasitized mice

Georgewill UO, Adikwu E, Ebong NO

Background: Desloratadine/dihydroartemisinin/piperaquine (DL/D/P) can be used for malaria treatment, but its safety assessment is imperative.

Drug Discovery, 2022, 16(37), 36-44

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Renal impact of desloratadine/dihydroartemisinin/piperaquine on healthy and parasitized mice

Georgewill UO, Ebong NO, Adikwu E

Desloratadine/dihydroartemisinin/piperaquine (DL/D/P) showed promising therapeutic activity on Plasmodium berghei. This study evaluated its renal impact on healthy and Plasmodium berghei-infected mice.

Drug Discovery, 2022, 16(37), 45-52

Abstract | PDF

ANALYSIS

Antimicrobial activities of hydrazones with 2,4-dichloro moiety

Babalola SA, Igie N, Idris AY, Hamza A, Sanni YM, Muhammad HY, Erumiseli OG, Bakare LO

The goal of this research was to come up with novel antibacterial agents. Two hydrazones with 2,4-dichloro moiety were synthesized by conventional synthetic methods with good yields

Drug Discovery, 2022, 16(37), 53-62

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REPORT

Solvent-free synthesis of polymethoxy and dichloro p-nitrophenyl hydrazones

Babalola SA, Idris AY, Sani YM, Hamza A, Igie N, Muhammad H, Erumiseli OG, Bakare LO

A solvent-free method for the synthesis of novel p-nitrophenyl hydrazones was successfully developed.

Drug Discovery, 2022, 16(37), 63-67

Abstract | PDF

ANALYSIS

Phytochemical and antimicrobial studies of xylopia aethiopica stem bark extracts

Babalola SA, Gabriel AF

The preliminary screening of phytochemical constituents of extracts of Xylopia aethiopica was evaluated

Drug Discovery, 2022, 16(37), 68-75

Abstract | PDF


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