Volume 15, Issue 35, 2021 (In Progress)

About the Cover

In our ongoing search for anticancer compounds from natural products we chromatographed cytotoxic active extracts from medicinal plants growing in Omanin order to isolate their active ingredients. We hereby report isolation of a cytotoxic pimarane diterpenoid, 3-hydroxy-ent-pimara8(14),15-dien-19-oic acid (1) from hexane extract of Juniperus servaschanica collected from Oman. The anticancer property was evaluated against ovarian (MCAS) and breast (MDA MB231) cancer cell lines by Alamar-blue assay. Compound 1 was active against both ovarian and breast cancer cells (IC50 = 24.16 and 16.13 µg/ml, respectively). Additionally, the molecule showed little damaging effect against non-cancerous cells, fibroblast at its IC50 dosage. Further investigation on this metabolite and its derivatives might lead to discovery of new chemical entities for control of cancer.

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ANALYSIS

A pimarane diterpene from Juniper servaschanica inhibits growth of Ovarian and Breast Cancer Cells

Sadri Abdullah Said, Yahya Tamimi, Afaf Mohd Weli, Md Sohail Akhtar

In our ongoing search for anticancer compounds from natural products we chromatographed cytotoxic active extracts from medicinal plants growing in Omanin order to isolate their active ingredients

Drug Discovery, 2021, 15(35), 1-5

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Development and Characterization of Tolvaptan HCl Fast Dissolving Tablets

Raghavendra Kumar Gunda, Prasada Rao Manchineni, Rajini Sudireddy

Objective: The purpose of present investigation to formulate, characterize the oral dissolving tablets (ODT) for Tolvaptan HCl. Tolvaptan HCl, a newer aquaretic sorvaptan

Drug Discovery, 2021, 15(35), 6-15

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REPORT

Isolation, cloning and transformation of glucan binding protein (GBP) gene

Ravikumar Patil HS, Vasantha Naik T, Vijay Avin BR, Sayeswara HA

This work was to isolate the glucan binding protein (gbp) gene from Streptococcus mutans, it possesses at least four glucan binding proteins GbpA, GbpB, GbpC, and GbpD, each of which appears to be immunologically and biochemically distinct using various processes

Drug Discovery, 2021, 15(35), 16-22

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REVIEW

A novel and Emerging Coronavirus Infection: Repurposing and Scale of Advances of Therapeutics, Imunotherapeutics and Vaccine Development

Tapas Kumar Mohapatra, Reena Rani Nayak, Arijit Mondal, Sitansu Sekhar Nanda

A new coronavirus (nCOVID-19) has appeared in China for the first time, inducing various effects in humans and strongly linked to those induced by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome)

Drug Discovery, 2021, 15(35), 23-50

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RESEARCH

Ameliorative effect of a multi-nutrient-rich product against cyanide induced hepatorenotoxicity

Ilesanmi O. Babatunde, Asaba Abigai

The present study was designed to investigate the protective effects of trevo, on potassium cyanide-induced hepato- and nephrotoxicity in male Wistar rats

Drug Discovery, 2021, 15(35), 51-59

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REPORT

A novel validated method for estimation of Carbachol in ophthalmic preparations by spectrophotometer

Abdul Munan, Akhtar Jamal Khan, Mahwash Khan, Abdul Haleem, Muhammad Ishaq Nazeer

A simple and selective novel spectrophotometric method has been proposed for determination of Carbachol in pure and pharmaceutical ophthalmic preparations. The method is developed on formation of ion-pair complex between Bromophenol blue (BPB) and Carbachol (Carb), which is blue in color

Drug Discovery, 2021, 15(35), 60-68

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RESEARCH

Effects of Novel Silver (I) NHeterocyclic Carbene Complexes on Mycotoxin Producing Fungi and Biofilm Forming Microorganisms

Esin Poyrazoğlu Çoban, Engin Ertuğrul, Rukiye Fırıncı, Halil Bıyık, Muhammet Emin Günay

Ag (I) complexes were prepared for a series of NHC substituents. Firstly, NHC precursors (1-9) were synthesized. In the second step, Ag (I) -NHC complexes (10-15) were synthesized. Structure of silver (I) N-heterocyclic carbene complexes was analysed using 1H- and 13C-NMR spectroscopy

Drug Discovery, 2021, 15(35), 69-79

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