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Volume 14, Issue 34, 2020

About the Cover

Molecular nanomachines are artificial or biological components which are in need to communicate with each other to perform a specific task. For this purpose, we consider two nanomachines called as transmitter nanomachine (TN) and receiver nanomachine (RN). TN transmits molecules in environment and RN receives the molecules through receptors, thus enabling them to communicate each other. The mathematical model which is based on ligand receptor binding is simulated in matlab code. The simulation results show that concentration of molecules, threshold concentration, pulse duration and temperature of environment affect on the channel capacity and thus appropriate values are be selected to achieve for maximum capacity of communication.


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ANALYSIS

Simulation study of a mathematical model of molecular communication based on ligand-receptor binding

Indrajit Sharma B

Molecular nanomachines are artificial or biological components which are in need to communicate with each other to perform a specific task. For this purpose, we consider two nanomachines called as transmitter nanomachine (TN) and receiver nanomachine (RN)

Drug Discovery, 2020, 14(34), 189-196

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PERSPECTIVE

Current developments of potentially significant Triazole derivatives

Mohammad Asif

Heterocyclic compounds analogues have attracted strong interest due to their useful pharmacological properties. Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities.

Drug Discovery, 2020, 14(34), 197-211

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ANALYSIS

The comparative study of basicities, Li+ and Na+ affinities of a series of heterocyclic molecules (Pyrrole, Furan, Thiophene and Pyridine) in the ground state - A DFT Study

Biswarup Mandal, Bikash Kumar Panda, Suman Sengupta

A comparative study of the proton affinities (PA), Li+ affinities and Na+ affinities of a series of heterocyclic molecules Pyrrole, Furan, Thiophene and pyridine and their protonated, lithium and sodium complexes in the gas phase have been performed theoretically by B3LYP (DFT) method

Drug Discovery, 2020, 14(34), 212-216

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RESEARCH

Effects of Polyalthia longifolia leaves against streptozotocin-nicotinamide induced type 2 diabetes mellitus and peripheral neuropathy in rats

Andichettiar Thirumalaisamy Sivashanmugam, Tapan Kumar Chatterjee

Polyalthia longifolia (Sonner.) Thw. (Annonaceae) has been used in Ayurveda for treating fever, skin diseases, diabetes, hypertension and helminthiasis. This study evaluates the protection against type 2 diabetes and diabetic neuropathy by Polyalthia longifolia leaves

Drug Discovery, 2020, 14(34), 217-230

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Analysis of adverse reactions associated with use of psychiatric medications in a teaching hospital - A retrospective study

Lakshmi Prasanna T, Stalin C, Ramachandra Bhat C

Drug therapy for psychiatric disorders is frequently associated with various adverse drug reactions (ADRs). Our study was based on analyzing the reports received by spontaneous ADR reporting program.

Drug Discovery, 2020, 14(34), 231-237

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REPORT

The proton affinities of a sequence of β-substituted acrylamide in the ground state: A DFT based computational approach

Biswarup Mandal, Umasankar Senapati, Bhudeb Ranjan De

A detailed study of the proton affinities of a series of β-substituted acrylamides and their O-protonated counterparts has been performed by B3LYP (DFT) method using 6-311G (d,p) basis sets with complete geometry optimization both before and after protonation

Drug Discovery, 2020, 14(34), 238-245

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Serological analysis for torch infection in women with bad obstetric record

Aresh N, Vishwa Bharathi HA, Chitra S

Infant death within utero or at delivery has always been a disgraceful occurrence for perinatal death and remains a dispute in the concern of pregnant women worldwide.

Drug Discovery, 2020, 14(34), 246-251

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Effect of the supplemented dietary iron in the biological cycle among the adolescent girls

Ilangovan M, Chandra Prabha D, Narayanasamy K, Nirmala Devi N, Rathi MA

Anemia is primarily a metabolic disorder marked by a progressive decline in the iron content in the blood. It is considered to be silent with no early warning signs. Iron-deficiency anemia is among the most common forms of health hazards in the world

Drug Discovery, 2020, 14(34), 252-254

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Antitumor activity of plant associated endophytic actinomycetes

Kanchanadevi D, Hemashenpagam N

The current analysis segregated the endophytic actinomycetes from bio-materials like cabbage (Brassica oleraecea), tomato (Solanum lycopersicum) and maize (Zea mays). The total 40 actinomycetes were isolated using Starch casein agar.

Drug Discovery, 2020, 14(34), 255-264

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ANALYSIS

Albizia lebbeck stem bark aqueous extract as alternative to antibiotic feed additives in broiler chicks diets: performance and nutrient retention

Alagbe JO, Shittu MD, Ajagbe Adekunle David

A study was conducted to examine the effect of Albizia lebbeck stem bark aqueous extract (ATSM) as alternative feed additives in broiler chicks diets: performance and nutrient retention.

Drug Discovery, 2020, 14(34), 265-275

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Albizia lebbeck stem bark aqueous extract as alternative to antibiotic feed additives in broiler chicks’ diets: haematology, serum indices and oxidative status

Alagbe JO, Ajagbe AD, Attama Jeremiah, Philemon KC, Bello Kamoru A

A total of Three hundred and seventy five (375) one day old (Ross 308) broiler chicks with mixed sex were used to examine the effects of Albizia lebbeck stem bark (ATSM) aqueous extract as alternative to antibiotic feed additives in broiler chicks diets: haematology, serum biochemical indices and oxidative status

Drug Discovery, 2020, 14(34), 276-284

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REPORT

Recent Advances in the Development of Salicylic Acid Analogues as Anti-Tubercular Agents

Mohammad Asif

Tuberculosis is still the second most crucial infectious disease globally. The effective treatment of tuberculosis is difficult due to the unusual cell wall structure and composition of mycobacteria, which makes many drugs ineffective and obstructs the entrance of drugs

Drug Discovery, 2020, 14(34), 285-289

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Formulation and evaluation of microspheres loaded with methotrexate drug

Venkata Swamy M, Ramana Murthy KV

The main aim of the research work was the formulation and evaluation of controlled release microspheres loaded with methotrexate drug.

Drug Discovery, 2020, 14(34), 290-295

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RESEARCH

Synthesis and spectroscopic signatures of a novelpolylactide-based nano-organogel

Frank O. Ohwoavworhua, James W. Mitchell

The low molecular weight gelators (LMWGs) are small organic molecules known for their gel forming abilities. Depending on experimental conditions, these molecules self-assemble and immobilize organic solvents or water to form organogels or hydrogels, respectively

Drug Discovery, 2020, 14(34), 296-306

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REVIEW

Anti-tubercular Potential of Ethylenediamine Derivatives: A Short Review

Mohammad Asif

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Control of TB is complicated by the long-course therapy regimens, the incapability to eliminate latent organisms, and the increasing appearance of multidrug resistant strains of M. tuberculosis.

Drug Discovery, 2020, 14(34), 307-313

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ANALYSIS

Cellulose nanocrystals and nanofibrils obtained from corn straw by hydrolytic action of four acids: particulate, powder and tablet properties

Frank O Ohwoavworhua, Augustine O Okhamafe

Nanocellulose derived by the hydrolysis of alpha cellulose of corn straw using different acids has been examined. Its particulate and structural characteristics including morphology (SEM), thermal behavior (DSC) and crystallinity (XRD) showed dependence on the acid type

Drug Discovery, 2020, 14(34), 314-327

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Validated UV and HPLC method development for the estimation of sofosbuvirin marketed formulation

Vandana Sinha, Priyanka Chaturvedi, Manish Sharma, Anurag Singh, Surendra Jain

In the present research work, a successful attempt was made for Validated UV and HPLC method which was developed by experimentation based on thorough literature survey and ascertained by statistical parameters of sampling

Drug Discovery, 2020, 14(34), 328-336

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Functionality assessment of microcrystalline cellulose derived from rice husk as a pharmaceutical excipient

Frank O Ohwoavworhua, Augustine O Okhamafe

Herein, microcrystalline cellulose obtained from rice husk (RH-MCC) has been evaluated for its role as a diluent in ascorbic acid tablet formulation, as well as disintegrant in dicalcium phosphate (DCP) compacts.

Drug Discovery, 2020, 14(34), 337-345

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