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Volume 13, 2019

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Histomorphological assessment of the testes and some blood parameters of mice exposed to the ethanolic seed extract of Mucuna urens were investigated in 24 male mice weighing between 20-30g. The mice were divided into 4 groups of 6 animals each. Group 1 was the control while group 2, 3 and 4 were the experimental groups. 80 seeds of Mucuna urens were used and the content was extracted using 1000mls of absolute alcohol. Filtered and dried in water-bath of 45°C. 1000mg of the extract was dissolved in 50mls of distilled water and 50mls of 30% of tween 80. The extract was administered orally for 7 days. Group 1 was administered 5ml distilled water, group 2 were administered 100mg/kg of ethanolic seed extract of Mucuna urens, group 3 were administered 200mg/kg of ethanol seed extract of Mucuna urens and group 4 were administered 300mg/kg of ethanolic seed extract of Mucuna urens. After sacrifice, cardiac puncture was done for hemoglobin (HB) count and Pack cell Volume (PCV) determination. Data were analysed using descriptive statistics and ANOVA.


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ANALYSIS

Evaluating the effects of Mucuna urens (Ibaba) on the body/organ weights and some haematological indices in male mice

Gabriel D Edem, Iboro E Edet, Uwemedimo G Udoh, Emmanuel B Etuk, Atairek-Awaji A Simeon

Histomorphological assessment of the testes and some blood parameters of mice exposed to the ethanolic seed extract of Mucuna urens were investigated in 24 male mice weighing between 20-30g.

Drug Discovery, 2019, 13, 1-5

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RESEARCH

Synthesis and biological evaluation of some “N” containing heterocyclic Schiff base metal complexes

Anupama B, Chenchu Lakshmi KNV, Reshma Chowdary B, Ch.Vennela

A new Schiff base has synthesized from 4-(1H-benzo[d]imidazol-2-yl) aniline and different aromatic carbonyl compounds. Metal complexes of the Schiff base have been synthesized from salts Fe (II), Ag (II) metal in the alcoholic medium.

Drug Discovery, 2019, 13, 6-9

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In vitro and In vivo Antiproliferative activity of extracts and fractions of leaves and stem from Tabebuia hypoleuca (C. Wright) Urb.

Luz María Sánchez Perera, Ada Ivis Regalado Veloz, Ana Lúcia Tasca GoisRuiz, Mary Ann Foglio, Ilza Maria de Oliveira Sousa, Sirlene Valério Tinti, Ana Possenti, João Ernesto de Carvalho

Tabebuia hypoleuca (C. Wright) Urb. Is Cuban endemic plant without preview study as antitumor, however these genera had been reported with several pharmacological activities.

Drug Discovery, 2019, 13, 10-21

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ANALYSIS

Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde

Elena Prokopchuk, Alexandra Aleksandrova, Iryna Kravchenko

The physiological role of pain helps to avoid or limit the tissue damage and therefore it provides the vital protective function. It has been previously studied, that complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde as well as their components represent the practical interest by the manifestation of anti-inflammatory and antidepressive action.

Drug Discovery, 2019, 13, 22-25

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METHOD

Design, ultrasound assisted Synthesis and anticancer screening of 4-[5-(aryl)-4, 5-dihydro-1H-pyrazol-3-yl]-3-(substituted phenyl) sydnones

Sachin K Bhosale, Shreenivas R Deshpande, Rajendra D Wagh, Nirmala V Shinde

Present research work focused to green synthesis of novel mesoionic compounds containing sydnone moiety and their anticancer screening.

Drug Discovery, 2019, 13, 26-38

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RESEARCH

Development of olive leaf extract loaded fibroin microparticles by spray drying

Oguz Bayraktar, Merve Deniz Köse, Yucel Baspinar

Recently, natural bioactive compounds have been the focus of many health related biotechnology studies. In order to enhance the stability of the natural bioactive compounds appropriate carrier systems are certainly needed to protect them from harsh environmental conditions and also control their release rates.

Drug Discovery, 2019, 13, 39-45

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In vitro anticancer activity of Melastomastrum capitatum Fern. loaded chitosan nanoparticles on selected cancer cells

Cletus A Ukwubile, Abubakar Ahmed, Umar A Katsayal, Jamilu Ya'u, Henry I Nettey

Chitosan nanoparticles are used for drug delivery because, they allow drugs to be selectively targeted to organs thereby minimizing injuries.

Drug Discovery, 2019, 13, 46-54

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ANALYSIS

Isolation and antiproliferative characterisation of bergenin from root extract of Uvariodendron anisatum Verdec (Annonaceae)

Onyancha JM, Gikonyo NK, Wachira SW, Gicheru MM

Uvariodendron anisatum (annonaceae) is a rare, endemic and indigenous medicinal plant in Kenya. The plant root decoction is used to remove placenta in women if it is retained during child deliveries.

Drug Discovery, 2019, 13, 55-78

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REPORT

Rice husk as a sustainable source of microcrystalline cellulose: pharmacopoeial, crystalline and spectroscopic characteristics

Frank O Ohwoavworhua, James W Mitchell, Augustine O Okhamafe

Herein, we report the use of three methods to pulp rice husks to find a method that results in near lignin-free pulp. Using dilute hydrochloric acid, the near lignin-free pulp (α-cellulose) was depolymerized into microcrystalline cellulose

Drug Discovery, 2019, 13, 79-87

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In-vitro Cytotoxicity studies of psidium guajava against Ehrlich ascites carcinoma cell lines

Shakeera Banu M, Sujatha K

The Current research explains the in-vitro anticancer activity of psidium guajava plant extract against Ehrlich ascites carcinoma cell lines.

Drug Discovery, 2019, 13, 88-94

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ANALYSIS

Studies on the anticonvulsant and sedative effects of Jatropha curcas (Euphorbiaceae) and Phragmanthera capitata (Loranthaceae) in mice

Bonaventure Chinonso Obi, Zelinjo Igweze, Victoria Nwaogu, Christine Ben, Theophine Chinwuba Akunne

The species of Jatropha curcas and Phragmanthera capitata are used in the treatment of various ailments in African traditional medicine such as insomnia and convulsive disorders.

Drug Discovery, 2019, 13, 95-102

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REPORT

A simple RP-HPLC method for Acyclovir determination in tablet and cream dosage forms

Bushra T Al Quadeib

A simple, rapid, accurate, and precise reverse phase HPLC (RP-HPLC) method was developed and validated for the determination of acyclovir (ACV) present in the pharmaceutical dosage form

Drug Discovery, 2019, 13, 107-114

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ANALYSIS

Ligand efficiency: The In-Silico insight to Drug Design

Jean-Bertrand Leroux, Alexander Bukhvostov, Lidiya Iliyenko, Anton Dvornikov, Nimah Amirshahi, Dmitry Kuznetsov

Ligand efficiency is a widely used design parameter in drug discovery. The dependence of ligand efficiency on the concentration unit can be eliminated by defining efficiency in terms of sensitivity of affinity to molecular size and this is illustrated with reference to fragment-to-lead optimizations.

Drug Discovery, 2019, 13, 115-128

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RESEARCH

Anti-inflammatory activity of fractions and isolated compounds from Tabebuia hypoleuca stems in mice

Ada Ivis Regalado Veloz, Luz María Sánchez Perera, Betty Mancebo Dorvigny, Ilza Maria de Oliveira, Mary Ann Flogio

In the literature, there are few studies on the species Tabebuia hypoleuca. So far, only the anti-inflammatory activity of stems methanol extract is reported in two models of acute inflammation

Drug Discovery, 2019, 13, 129-137

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Investigation of chronic anti-inflammatory activity of methanol extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems

Ada I. Regalado Veloz, Luz M. Sánchez Perera

Background: Tabebuia spp. has been traditionally used to treatment of different illness. We reported in previous paper the antiinflammatory activity on acute inflammation models, antinociceptive and antipyretic effect from methanol extract of Tabebuia hypoleuca stem.

Drug Discovery, 2019, 13, 138-146

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