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Volume 12, 2018

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This research evaluated the phytochemical contents and analgesic properties of ethanol extract of Hibiscus sabdariffa. Fresh leaves of H. Sabdariffa were obtained, dried and milled. The samples were then analyzed for phytochemical composition using standard methods. The analgesic property was done using 20wistar albino rats weighing 80-120 g and grouped into 5 different groups (n=4). Group one served as control and received only feed and water ad libitum, group 2: received morphine, intraperitoneally and Group 3, 4, and 5 received Hibiscus sabdariffa ethanol leaf extract (250, 500, 750 mg/kg) orally, respectively. The photochemical result shows the presence of flavonoids (28.66 %) and tannins (30.43 %) as the highest phytochemicals while others are alkaloids (20.74 %), phenols (18.93 %), cardiac glycosides (5.70 %) and saponins (15.60 %).The analgesic result showed that significance percentage inhibition of writhing (p<0.05) at 750 mg/kg bw which showed similar potency as morphine. Therefore, these results show that H. Sabdariffa can be used as an analgesic when consumed in a high concentration.


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ANALYSIS

Studies on phytochemical screening, Antibacterial potential and Hemostatic activity of Tridax procumbens

Dhivyavarshni R, Sagadevan P, Jayaram Jayaraj K, Chandar Shekar B, Ranjth Kumar R, Rathish Kumar S

Nature always stands as a golden mark to exemplify the outstanding phenomenon of symbiosis. The plants are indispensable to man for his life. Nature has provided a complete store house of remedies to cure all ailments of mankind.

Drug Discovery, 2018, 12, 1-6

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RESEARCH

Biogenic synthesis of silver nanoparticles and their antioxidant and antibacterial activity aqueous leaf extracts of Centella asiatica Linn

Saranya S, Sagadevan P, Senthikumar V, Janarthanan P, Jayaramjayraj K

The present study, a simple and eco-friendly, biosynthesis of silver nanoparticles using the plant leaves of Centella asiatica. In this study, AgNPs were synthesized extra cellular by Centella asiatica at room temperature. The AgNPs were quite stable without using any toxic chemicals as capping agents

Drug Discovery, 2018, 12, 7-20

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ANALYSIS

Green synthesis of sliver nanoparticles using piper betle aqueous leaf extract

Thilagavathi R, Sagadevan P, Senthikumar V, Janarthanan P, Jyaramjayaraj K

In the present work was undertaken with a preliminary phytochemical screening of betel leaves showed the presence of active compound in the aqueous extract. The aqueous extract of betel leaves showed the presence of preliminary phytochemical such as alkaloids flavonoids, Saponins, tannins terpenoids and glycoside substance.

Drug Discovery, 2018, 12, 21-30

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Phytochemical content and analgesic activity of ethanol extract of Hibiscus Sabdariffa in experimental animal model.

Omodamiro OD, Achi NK, Jimoh MA

In the present work was undertaken with a preliminary phytochemical screening of betel leaves showed the presence of active compound in the aqueous extract. The aqueous extract of betel leaves showed the presence of preliminary phytochemical such as alkaloids flavonoids, Saponins, tannins terpenoids and glycoside substance.

Drug Discovery, 2018, 12, 31-37

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REPORT

Phytochemical screening and evaluation of antifertility activities of Rhus mysorensis in female albino rats

Bhavya E, Gunasekaran V, Jayabalan G

It is well known that the plant kingdom contains numerous bioactive substances affecting the regulation of reproduction. This study was aimed at screening the phytochemicals and antifertility activity of methanolic extract of root Rhus mysorensis. The phytochemical analysis was carried out using standard methods.

Drug Discovery, 2018, 12, 38-41

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Exploring the anti-inflammatory potentials of N-((5-(((1,3- dioxoisoindolin-2-yl)methyl)amino)-1,3,4-thiadiazol-2- yl)methyl)benzamide

Debarshi Kar Mahapatra, Kanhaiya M Dadure, Animeshchandra GM Haldar

In the process of drug discovery, several non-steroidal anti-inflammatory drugs (NSAIDs) have been developed, however, a majority of them suffered from pharmacodynamics, pharmacokinetic, side-effects, or adverse drug reactions, which compelled researchers for continuous searching for better alternatives.

Drug Discovery, 2018, 12, 42-45

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ANALYSIS

Quantitative determination of microelements in Ginkgo biloba L. leaves, harvested in Ukraine

Lysiuk RM, Darmohray RY, Tsal OY, Bitlian VI

Ginkgo biloba, that is widely used to treat various diseases due to the numerous bioactive compounds, attracts considerable investigation interest

Drug Discovery, 2018, 12, 46-48

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Antimicrobial potential of crude extracts from Sea slug, Euselenops luniceps (Cuvier, 1817)

Sivaprakasam Ramya, Samuthirapandian Ravichandran, Kannan Mohan

To evaluate the anti-microbial potential of Euselenops luniceps, locally known as ‘Moon-headed sidegill slug’, which one of the sea slug species. The in vitro anti-microbial assay was carry out by disc diffusion method.

Drug Discovery, 2018, 12, 49-53

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Hepatotoxicity, Hyperglycemic and hyperlipidemic effect of Aqeous Leaf Extract of Nicotianatabaccum in male Wistar albino rats

Nweze Chibuzo Carole, Nweze OtitoAdaeze

To evaluate the anti-microbial potential of Euselenops luniceps, locally known as ‘Moon-headed sidegill slug’, which one of the sea slug species. The in vitro anti-microbial assay was carry out by disc diffusion method.

Drug Discovery, 2018, 12, 54-58

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Spectral investigation of 3,4,5 Tri Methoxy Benzaldehyde-Atomoxetine Cu(ii) & Ru(ii) Schiff base metal complexes & its biological activity

Anjaneya Vasavi GSS, Sreeramulu J, Subba Reddy GV

A series of New Schiff base Metal Complexes of Cu(II) & Ru(II) were synthesized by the condensation of Atomoxetine with 3,4,5 Tri Methoxy Benzaldehyde. These metal complexes were characterized by Elemental Analysis, UV-VISIBLE, IR, SEM, TG-DTA, PowerXRD & Molar conductance.

Drug Discovery, 2018, 12, 59-65

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REVIEW

Genetic and Molecular Mechanisms Associated with Antibiotic Resistance in Methicillin Resistant Staphylococcus aureus (MRSA): A Review

Diso SU, Mukhtar MD, Dutsin-Ma UA, Ali M

A series of New Schiff base Metal Complexes of Cu(II) & Ru(II) were synthesized by the condensation of Atomoxetine with 3,4,5 Tri Methoxy Benzaldehyde. These metal complexes were characterized by Elemental Analysis, UV-VISIBLE, IR, SEM, TG-DTA, PowerXRD & Molar conductance.

Drug Discovery, 2018, 12, 66-71

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REPORT

Characterization of bacteria associated with untreated otitis media with effusion among primary school children in Kano Metropolis, Nigeria

Nas FS, Ali M, Aminu MA, Nasiru AS

Otitis media with effusion is an inflammation of the middle ear in which fluid accumulates behind the eardrum. The aim of the study was to determine the bacteria isolates associated with untreated otitis media with effusion among primary school children in Kano metropolis Nigeria

Drug Discovery, 2018, 12, 72-75

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PERSPECTIVE

Proteins as the molecular markers of male fertility

Eswari Beeram

Proteins play a key role in many functions such as metabolic activity, differentiation, as cargos and cell fate regulators. It is necessary to know about the markers involved in male fertility in order to develop remedies for the treatment of male infertility.

Drug Discovery, 2018, 12, 76-80

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