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Volume 10, 2015

About the Cover

This study is aimed to determine the effect of drug (herbal and allopathic) on the JPH2. JPH2 protein sequence was collected from Uni-Prot. The composition of amino acids was determined by using Protparam. The tertiary structure of JPH2 was predicted by using CPH modeling server and visualized through Rasmol. Ramachandran plot was performed for JPH2 using Rampage software. The active sites were predicted by CASTp. The docking of Junctophilin-2 protein with selected one herbal antibiotic (TOCOPHEROL) and one allopathic antibiotic (BISOPROLOL) was performed by the use of the tool Hex 6.3.


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RESEARCH

Can allosteric inhibitors of adamts4 and adamts5 prevent osteoarthritis disease progression?

Bondeson J, Wainwright S, Hughes CE, Caterson B

The success of targeted biologic therapy against rheumatoid arthritis and other inflammatory conditions has led to much interest in the pathophysiology of osteoarthritis, in the hope of defining novel therapeutic targets.

Drug Discovery, 2015, 10(23), 5-14

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ANALYSIS

Herbal Active Components act as Inhibitor against HCV NS3/4A protease by Using Bioinformatics Approach

Prabhakar Semwal, Raghav Tripathi, Ashish Thapliyal

Hepatitis C is a worldwide liver disease caused by the hepatitis C virus. There is no vaccine available in the market for the treatment of this virus. There is a strong requirement to develop an antiviral compound that can modulate/target the HCV genotypes.

Drug Discovery, 2015, 10(23), 15-21

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Phenytoin, Azadirachta indica and Rheum palmatum inhibits angiogenesis, proliferation and invasion of blood capillaries in implanted sponge by various postulated mechanisms: A pre-clinical screening

Vijay R Chidrawar, Chandana Kamili, Poulami Dey, Uma Maheshwararao Vattikutti

Angiogenesis is the growth of new blood vessels. It mostly occurs where Vascular endothelial Growth factors (VEGF) gets triggered and leads to Endothelial Cell proliferation and thus leading to formation of new blood vessels.

Drug Discovery, 2015, 10(23), 22-31

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FDA APPROVED DRUGS

FDA approved drugs – December 2014

Vidhya

Zerbaxa is a combination of ceftolozane and tazobactam. Ceftolozane belongs to the cephalosporin class of antibacterial drugs. The bactericidal action of ceftolozane results from inhibition of cell wall biosynthesis, and is mediated through binding to penicillin-binding proteins (PBPs).

Drug Discovery, 2015, 10(24), 32-37

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FDA approved drugs – January 2015

Vidhya

Rytary is an extended release formulation of carbidopa and levodopa. Carbidopa: When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.

Drug Discovery, 2015, 10(24), 38-41

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FDA approved drugs – February 2015

Vidhya

Avycaz (ceftazidime-avibactam) is a combination of a cephalosporin and a beta-lactamase inhibitor. In combination with metronidazole, it is used for the treatment of complicated intra-abdominal infections (cIAI) caused by the following susceptible microorganisms.

Drug Discovery, 2015, 10(24), 42-44

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RESEARCH

Study of Junctopholin 2 (JPH2) protein and its binding efficiency with herbal and allopathic antibiotics

Sathish P, Ruba Glory P, Palanivelu K

This study is aimed to determine the effect of drug (herbal and allopathic) on the JPH2. JPH2 protein sequence was collected from Uni-Prot. The composition of amino acids was determined by using Protparam.

Drug Discovery, 2015, 10(24), 45-55

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Chemical characterization of Gomutra (GIR) by high resolution high performance liquid chromatography

Bismi Nivethitha R, Padma Priya SS

Cow urine has lot of application in medicine Cow urine provides immunity power by increasing resistance power against diseases in human body. It is anti toxin. It has been found that cow urine has potential to control amongst cow urine is best their entire exercise of marketing the cow products and promising huge economic benefits.

Drug Discovery, 2015, 10(24), 56-66

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Immunomodulatory Efficiency of Cow Urine Distillate (CUD) on the Haematology of Oreochromis mossambicus (Peters)

Mala G, Venkatalakshmi S

Cow, Bos indicus is mentioned as the most valuable animal in all Veda and it is called as the mother of all. The composition Cow’s excretions, Urine, dung, milk, curd and ghee, the five ingredients together known as Panchagavga is the main ingredient of many of our ayurvedic preparations.

Drug Discovery, 2015, 10(24), 67-75

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Optimization of Concentration of Bos indicus Cow Urine Distillate (CUD) in Oreochromis mossambicus (Peter) for Immunostimulatory activity

Durga B, Mala G, Venkatlakshmi S

Cows were regarded as wealth and were the backbone of the economy of ancient Indians. The sacred Indian cow, Bos indicus, is believed to be a “mobile hospital” for the treatment of many diseases. Wars were fought for acquiring cows.

Drug Discovery, 2015, 10(24), 76-83

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Study on the relative efficacy of indigenous plant extracts as larvicide against the mosquito Culex quiquefasciatus (Say.)

Logambal SM, Venkatalakshmi S

There has been considerable concern for the past few decades about the excessive use of chemical pesticides both in agriculture and for control of vector borne diseases. It has become increasingly difficult to control mosquitoes that serve as vector for various diseases.

Drug Discovery, 2015, 10(24), 84-92

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ANALYSIS

Variable drug bio availability of native seaweeds in India for antimalarial therapeutics

Margaret beula J, Sona Selva Malar S, Prasannakumar S, Ravikumar S, Kumaran R

A most important feature for the success of any planned reaction is the selection of a suitable solvent: solvents influence both chemical reactivity and reaction rates. The term “solvent polarity” lacks an exact definition, but it is generally used to encompass all of the intermolecular interactions of which the solvent is capable.

Drug Discovery, 2015, 10(25), 93-99

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OPINION

Calcium Supplementation: Cardiovascular Cure or Curse?

Shashi K Agarwal

Calcium supplements are taken by more than half of middle aged or older US women. Although better bone health is the purported reason, data supporting this association is only marginal.

Drug Discovery, 2015, 10(25), 100-102

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RESEARCH

Mucosal wound healing and anti peptic ulcer effect of Gongronema latifolium in rats

Azikiwe CCA, Aroh GN, Enye JC, Amazu LU, Ifezulike CC

The freshly leaves and stem of Gongronema latifolium is eaten as vegetables in most part of tropical Africa and used in treatment of peptic ulcer disease in folklore medicine. The air dried methanolic leave extract was investigated for anti-peptic ulcer and mucosal wound healing effect on indomethacin-induced gastric and duodenal ulcers in rats in order to demonstrate the pharmacological activity of the plants and justify its use in healing.

Drug Discovery, 2015, 10(25), 103-112

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The potential organo-toxicity safety of Morpholine and Crinum jagus in rats

Azikiwe CCA, Aroh GN, Enye JC, Amazu LU, Ifezulike CC

Crinum jagus is a medicinal plant used by traditional medicine healers and has active components as morpholine, hamayne and lycoline. Anticonvulsant and other activities of the plant exist in literature.

Drug Discovery, 2015, 10(25), 113-120

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Designing novel oral-Insulin conjugates for the development of oral-Insulin tablet: Inulin-Insulin conjugate is an efficient form for oral- Insulin tablet

Seenivasagam R

Insulin is used medically to manage diabetes mellitus by frequent subcutaneous injections have turned into a part of life can be enormously distressing for patients. Hence, we anticipate to getting rid of the usage of subcutaneous injections completely.

Drug Discovery, 2015, 10(26), 121-249

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COMMUNICATION

FDA approved drugs – June 2015

Vidhya V

Kengreal is specifically indicated as an adjunct to percutaneous coronary intervention for reducing the risk of periprocedural myocardial infarction, repeat coronary revascularization, and stent thrombosis in patients who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor.

Drug Discovery, 2015, 10(26), 250-251

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FDA approved drugs – July 2015

Vidhya V

Entresto is specifically indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It is supplied as a tablet for oral administration.

Drug Discovery, 2015, 10(26), 252-256

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FDA approved drugs – August 2015

Vidhya V

Addyi is specifically indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

Drug Discovery, 2015, 10(26), 257-260

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