This study is aimed to determine the effect of drug (herbal and allopathic) on the JPH2. JPH2 protein sequence was collected from Uni-Prot. The composition of amino acids was determined by using Protparam. The tertiary structure of JPH2 was predicted by using CPH modeling server and visualized through Rasmol. Ramachandran plot was performed for JPH2 using Rampage software. The active sites were predicted by CASTp. The docking of Junctophilin-2 protein with selected one herbal antibiotic (TOCOPHEROL) and one allopathic antibiotic (BISOPROLOL) was performed by the use of the tool Hex 6.3.
The success of targeted biologic therapy against rheumatoid arthritis and other inflammatory conditions has led to much interest in the pathophysiology of osteoarthritis, in the hope of defining novel therapeutic targets.
Hepatitis C is a worldwide liver disease caused by the hepatitis C virus. There is no vaccine available in the market for the treatment of this virus. There is a strong requirement to develop an antiviral compound that can modulate/target the HCV genotypes.
Angiogenesis is the growth of new blood vessels. It mostly occurs where Vascular endothelial Growth factors (VEGF) gets triggered and leads to Endothelial Cell proliferation and thus leading to formation of new blood vessels.
Zerbaxa is a combination of ceftolozane and tazobactam. Ceftolozane belongs to the cephalosporin class of antibacterial drugs. The bactericidal action of ceftolozane results from inhibition of cell wall biosynthesis, and is mediated through binding to penicillin-binding proteins (PBPs).
Rytary is an extended release formulation of carbidopa and levodopa. Carbidopa: When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.
Avycaz (ceftazidime-avibactam) is a combination of a cephalosporin and a beta-lactamase inhibitor. In combination with metronidazole, it is used for the treatment of complicated intra-abdominal infections (cIAI) caused by the following susceptible microorganisms.
This study is aimed to determine the effect of drug (herbal and allopathic) on the JPH2. JPH2 protein sequence was collected from Uni-Prot. The composition of amino acids was determined by using Protparam.
Cow urine has lot of application in medicine Cow urine provides immunity power by increasing resistance power against diseases in human body. It is anti toxin. It has been found that cow urine has potential to control amongst cow urine is best their entire exercise of marketing the cow products and promising huge economic benefits.
Cow, Bos indicus is mentioned as the most valuable animal in all Veda and it is called as the mother of all. The composition Cow’s excretions, Urine, dung, milk, curd and ghee, the five ingredients together known as Panchagavga is the main ingredient of many of our ayurvedic preparations.
Cows were regarded as wealth and were the backbone of the economy of ancient Indians. The sacred Indian cow, Bos indicus, is believed to be a “mobile hospital” for the treatment of many diseases. Wars were fought for acquiring cows.
There has been considerable concern for the past few decades about the excessive use of chemical pesticides both in agriculture and for control of vector borne diseases. It has become increasingly difficult to control mosquitoes that serve as vector for various diseases.
A most important feature for the success of any planned reaction is the selection of a suitable solvent: solvents influence both chemical reactivity and reaction rates. The term “solvent polarity” lacks an exact definition, but it is generally used to encompass all of the intermolecular interactions of which the solvent is capable.
Calcium supplements are taken by more than half of middle aged or older US women. Although better bone health is the purported reason, data supporting this association is only marginal.
The freshly leaves and stem of Gongronema latifolium is eaten as vegetables in most part of tropical Africa and used in treatment of peptic ulcer disease in folklore medicine. The air dried methanolic leave extract was investigated for anti-peptic ulcer and mucosal wound healing effect on indomethacin-induced gastric and duodenal ulcers in rats in order to demonstrate the pharmacological activity of the plants and justify its use in healing.
Crinum jagus is a medicinal plant used by traditional medicine healers and has active components as morpholine, hamayne and lycoline. Anticonvulsant and other activities of the plant exist in literature.
Insulin is used medically to manage diabetes mellitus by frequent subcutaneous injections have turned into a part of life can be enormously distressing for patients. Hence, we anticipate to getting rid of the usage of subcutaneous injections completely.
Kengreal is specifically indicated as an adjunct to percutaneous coronary intervention for reducing the risk of periprocedural myocardial infarction, repeat coronary revascularization, and stent thrombosis in patients who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor.
Entresto is specifically indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It is supplied as a tablet for oral administration.
Addyi is specifically indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty.
